The future of imaging is RUBY

Shaping Tomorrow: The PET Revolution.

Transforming cardiac care with precision, speed, and confidence.

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WHY PET BELONGS IN EVERY PRACTICE

Better care. 

Better outcomes.
Reduced costs.

Healthcare reform focuses on three goals:1

  1. Better care for individuals
  2. Better health for populations
  3. Reduced costs

Cardiac care remains at the forefront:2

  • Heart disease is the leading cause of death worldwide
  • Claims more lives each year than all cancers combined
  • Despite a 40% decline in deaths over the last decade, the toll remains high

The Challenge

Deliver the right test for the right patient at the right time.

The Solution

Noninvasive cardiac PET imaging meets essential goals for optimal imaging in appropriate patients.

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Why PET Has Replaced SPECT

PET is the future

For decades, SPECT has crafted a baseline of care, but PET has advanced the industry in every critical measure: speed, precision, and safety.

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Accuracy and Confidence

  • PET offers the highest diagnostic accuracy, confirmed by evidence reviews3, 4
  • High spatial and contrast resolution with photon attenuation-free images for high sensitivity and specificity4
  • PET provides clear, artifact-free imaging, essential for confidence in diagnosis
  • PET identifies very low-risk patients, eliminating unnecessary tests and enabling timely referrals5

Shorter Acquisition Times

  • PET acquisition time: ~30 minutes6
  • SPECT acquisition time: 3–5 hours6

How We Protect Patients and Staff

  • PET dramatically reduces radiation exposure:5, 7, 8
    • PET: ~1 mSv
    • SPECT: 10–20 mSv
  • Studies confirm PET MPI significantly lowers radiation risk compared to SPECT

Strong Prognostic Power

  • PET identifies risk levels and adds incremental prognostic value9
  • Vasodilator stress PET improves survival prediction beyond clinical variables10
  • Left ventricular ejection fraction reserve adds independent predictive power10
  • PET can be an appropriate initial test for high-risk patients9
  • Adding CFR estimates reclassifies patients across risk levels:11
    • Correctly reclassified 34.8% of intermediate-risk patients15
    • Net reclassification improvement: 0.487 (95% CI: 0.262–0.731)

Advanced Imaging

Compared to SPECT, PET offers:11

  • Advanced PET camera technology (3D, PET/CT, Digital)11
  • Image quality unaffected by body shape or size5
  • Diagnostic clarity in complex multivessel CAD3
  • Attenuation correction reduces artifacts and false positives3,17

Case Study

PET changes the diagnosis

An eighty-year-old woman with hypertension and dyslipidemia presented with chest pain.

Patient

80-year-old female with hypertension and dyslipidemia

Initial SPECT MPI

Mild ischemia reported

Diagnosis

Cardiac catheterization confirmed left main disease and LAD stenosis (80%)

Surgery

Patient underwent CABG surgery

PET MPI

Severe ischemia reported

SPECT Glowing letters

EVIDENCE THAT PET DELIVERS

Proven accuracy.
Proven impact.

PACIFIC Trial Highlights:14

  • Prospective study of 208 patients with stable chest pain and suspected CAD
  • PET demonstrated the highest diagnostic accuracy compared to CCTA and SPECT

Sub-analysis on FFR:5

  • PET assesses microvasculature, unlike CT or CT-FFR
  • Outperformed FFR, CTA, and SPECT in diagnostic performance

Acute Chest Pain Outcomes:

  • Retrospective study of 21,242 ED visits16
  • PET MPI availability led to:
  • Shorter ED stays16
  • 40% less downstream testing compared to SPECT16

EXPERT ENDORSEMENT

Meeting quality goals for imaging

PET MPI delivers:

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Effective

High diagnostic accuracy

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Safe

Lower radiation exposure

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Efficient

5-minute acquisition times

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Patient-Centered

Ideal for critically ill, obese, or high-risk patients

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